IN SILICO ANALYSIS OF THE THERAPEUTIC POTENTIAL OF SPILANTHOL IN THE MANAGEMENT OF PAIN AND INFLAMMATION IN PERISTOMAL DERMATITIS:

AN INTEGRATED APPROACH

Visualizações: 22

Authors

  • Lívia Mardulce Fonseca Carvalha Ceuma University
  • Hellen Beatriz Monteiro Costa Ceuma University
  • Lucas Raick Dutra Torres Ceuma University
  • Luckian Emannuel Ferreira Melo Ceuma University
  • Samanda de Jesus Roland Pires Ceuma University

DOI:

https://doi.org/10.56579/prxis.v4i1.3183

Keywords:

Peristomal dermatitis, Molecular docking, Spilanthol, Network pharmacology, Inflammation

Abstract

This study investigated, through computational (in silico) simulations, the therapeutic potential of spilanthol, a compound extracted from the jambu plant (Spilanthes acmella), for treating pain and inflammation in peristomal dermatitis. Using network pharmacology, 29 molecular targets common to spilanthol and the disease were identified, with emphasis on the proteins NFKB1, PIK3CG, PIK3CA, and CCR2, which are crucial in inflammatory processes. Pharmacokinetic profile analysis (ADMET) indicated that spilanthol has favorable drug-like characteristics, despite potential risks of skin sensitization. Molecular docking confirmed the high binding affinity of spilanthol to the key targets PIK3CG and CCR2, validating its mechanism of action. The results position spilanthol as a promising multitarget agent for the development of new therapies for peristomal dermatitis, requiring experimental validation.

Author Biographies

Lívia Mardulce Fonseca Carvalha, Ceuma University

Undergraduate Student in Pharmacy, Ceuma University

Hellen Beatriz Monteiro Costa , Ceuma University

Undergraduate Student in the Pharmacy Program, Ceuma University, São Luís, Maranhão, Brazil.

Lucas Raick Dutra Torres , Ceuma University

Graduate Student in the Postgraduate Program in Applied Biosciences to Health, Ceuma University, São Luís, Maranhão, Brazil.

Luckian Emannuel Ferreira Melo, Ceuma University

Graduate Student in the Postgraduate Program in Applied Biosciences to Health, Ceuma University, São Luís, Maranhão, Brazil.

Samanda de Jesus Roland Pires , Ceuma University

Graduate Student in the Postgraduate Program in Applied Biosciences to Health, Ceuma University, São Luís, Maranhão, Brazil.

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Published

2026-02-25

How to Cite

Carvalha, L. M. F., Costa , H. B. M., Torres , L. R. D., Melo, L. E. F., & Pires , S. de J. R. (2026). IN SILICO ANALYSIS OF THE THERAPEUTIC POTENTIAL OF SPILANTHOL IN THE MANAGEMENT OF PAIN AND INFLAMMATION IN PERISTOMAL DERMATITIS: : AN INTEGRATED APPROACH. PRÁXIS EM SAÚDE , 4(1), 01–14. https://doi.org/10.56579/prxis.v4i1.3183

Issue

Vol. 4 No. 1 (2026): PRAXIS IN HEALTH JOURNAL

Section

ARTIGOS

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