INHIBITION OF STAPHYLOCOCCUS AUREUS STRAINS BY SECONDARY METABOLITES OF STREPTOMYCES SP.

Visualizações: 187

Authors

  • Gessiane dos Santos de Souza Ceuma University
  • Weldson Ricardo Silva Gomes Ceuma University
  • Ana Thalia Sousa Carvalho Ceuma University
  • Vitor da Silva Moraes Ceuma University
  • Matheus Silva Alves Ceuma University
  • Camila Guerra Martinez Ceuma University

DOI:

https://doi.org/10.56579/prxis.v4i1.3178

Keywords:

Metabolites, Bacterial Resistance, Bioactive Compounds

Abstract

Streptomyces is recognized for its ability to produce bioactive compounds with antimicrobial activity. This study evaluated the activity of metabolites from Streptomyces sp. against clinical strains of Staphylococcus aureus. The extract was obtained by submerged fermentation, followed by antimicrobial activity assays, agar diffusion tests, and determination of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Standard strains ATCC 25923, ATCC 29213, and the clinical strain IC 2141 were tested. The extract showed inhibition zones ranging from 17 ± 0.82 mm to 19.33 ± 1.15 mm. MIC and MBC analyses revealed significant inhibitory and bactericidal activity, with emphasis on strain IC 2141 (MIC and MBC of 625 µg/mL). The results demonstrate that Streptomyces produces metabolites with antibacterial potential, including activity against strains resistant to conventional antibiotics. It is concluded that actinobacteria represent a promising source of bioactive compounds, reinforcing the importance of microbial bioprospecting in the development of therapeutic alternatives.

Author Biographies

Gessiane dos Santos de Souza, Ceuma University

Master’s Program in Applied Biosciences to Health, Ceuma University

Weldson Ricardo Silva Gomes, Ceuma University

Master’s Program in Applied Biosciences to Health, Ceuma University, São Luís, Maranhão.

Ana Thalia Sousa Carvalho , Ceuma University

Undergraduate Student in the Biomedicine Program, Ceuma University, São Luís, Maranhão.

Vitor da Silva Moraes, Ceuma University

Undergraduate Student in the Biomedicine Program, Ceuma University, São Luís, Maranhão.

Matheus Silva Alves, Ceuma University

Professor of the Master’s Program in Applied Biosciences to Health, Ceuma University, São Luís, Maranhão.

Camila Guerra Martinez , Ceuma University

Professor of the Master’s Program in Applied Biosciences to Health, Ceuma University, São Luís, Maranhão.

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Published

2026-03-03

How to Cite

Souza, G. dos S. de, Gomes, W. R. S., Carvalho , A. T. S., Moraes, V. da S., Alves, M. S., & Martinez , C. G. (2026). INHIBITION OF STAPHYLOCOCCUS AUREUS STRAINS BY SECONDARY METABOLITES OF STREPTOMYCES SP. PRÁXIS EM SAÚDE , 4(1), 01–11. https://doi.org/10.56579/prxis.v4i1.3178

Issue

Vol. 4 No. 1 (2026): PRAXIS IN HEALTH JOURNAL

Section

ARTIGOS

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