A Revista Práxis em Saúde criada em 2023 tem como principal propósito reunir uma variedade de trabalhos que explorem perspectivas inter e multidisciplinares no amplo campo da saúde. Nosso compromisso consiste em promover abordagens que habilmente entrelacem teoria e prática, estabelecendo uma conexão significativa entre os conhecimentos teóricos e sua aplicação no contexto da saúde. Buscamos ser um ponto de convergência para pesquisadores e profissionais que desejam ultrapassar as fronteiras disciplinares, sem negligenciá-las, oferecendo um ambiente propício à troca de ideias e à integração de diversas perspectivas. A Revista Práxis em Saúde aspira, dessa forma, ser um veículo dinâmico e enriquecedor para a disseminação de conhecimento, superando as barreiras tradicionais e contribuindo significativamente para o avanço do entendimento e das práticas no campo da saúde. Em 2023 e 2024 a Revista Práxis em Saúde publicou edições anuais a partir de 2025 adotará a publicação semestral em fluxo contínuo.
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MATERNAL MENTAL HEALTH AFTER PRETERM BIRTH
Preterm birth and neonatal hospitalization may intensify the stress experienced by mothers, negatively affecting their mental health. This study aimed to analyze the risk of parental depression among mothers of preterm infants who remained hospitalized after birth. This was a cross-sectional, descriptive study involving 99 mothers of preterm infants referred to a Follow-up Program after hospital discharge. Mothers of full-term infants and infants with genetic syndromes were excluded. The Survey of Well-being of Young Children (SWYC-BR) was used to screen for the risk of parental depression. Data were analyzed descriptively. The results indicated a higher risk of parental depression during the first months of the infant’s life, followed by a progressive decline throughout the first year. These findings reinforce the importance of systematic monitoring of maternal mental health after hospital discharge, with interventions focused on family support and comprehensive care.
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ANIMAL-ASSISTED SERVICE AS A CLINICAL STRATEGY FOR AUTISM SPECTRUM DISORDER
This experience report describes the integration of the co-therapist dogs Nutella and Toddy (Labrador Retrievers) and Charlotte (Jack Russell Terrier) into speech-language therapy sessions with 23 children diagnosed with Autism Spectrum Disorder (ASD), including 20 boys and 3 girls of preschool and school age. The sessions were conducted weekly, lasting 40 minutes each, over a period of 12 weeks. The Behavioral Observation Protocol (PROC) and the Language Development Assessment – 2 (ADL-2) were administered at the beginning of the assessment process, followed by the development of Individualized Therapeutic Plans (ITPs), and reapplied at the end to compare outcomes. Analysis of the clinical records revealed greater engagement in therapeutic activities, reduced stereotyped behaviors, improved joint attention, increased eye contact, and a higher frequency of spontaneous word production. Examples included a child who began maintaining eye contact for up to 10 seconds and another who started using simple verbal commands. Family reports also demonstrated enthusiasm and positive expectations regarding the sessions. Despite the variability inherent to ASD and the absence of a control group, the findings are consistent with the literature, suggesting that Animal-Assisted Services (AAS) are a promising interdisciplinary resource to enrich speech-language pathology practice and promote communicative and social development.
ASSISTIVE TECHNOLOGIES IN THE COMMUNICATION REHABILITATION OF CHILDREN WITH AUTISM SPECTRUM DISORDER
Autism Spectrum Disorder (ASD) is characterized by significant impairments in communication, social interaction, and behavior, directly impacting individuals’ overall development and autonomy. Due to its complexity, ASD requires structured and continuous intervention, based on the integration of different professional areas, in order to enhance communicative, social, and cognitive skills. Multiprofessional practice is essential for the full development of individual potential and for promoting social inclusion, as it enables the sharing of knowledge and the development of joint rehabilitation strategies. In this context, Speech-Language Pathology plays a central role by acting both in auditory stimulation and in the implementation of functional communication strategies, including the use of Augmentative and Alternative Communication (AAC) resources. This study aims to report a clinical experience of multiprofessional speech-language intervention focused on enhancing functional communication in a child diagnosed with ASD, using the PODD (Pragmatic Organisation Dynamic Display) system as a mediating tool in the therapeutic process. The strategies employed, the observed outcomes, and the importance of family involvement and integrated work among professionals from different fields for rehabilitation success are described.
AUTISM SPECTRUM DISORDER AND SOCIAL SKILLS
The objective of this study was to conduct a literature review on Social Skills related to Autism Spectrum Disorder, considering the bibliographic and methodological characteristics as well as the results of full articles available for download. This is a bibliographic study of the integrative review type. The guiding question was: what do studies published between 2010 and 2024 say about the relationship between Social Skills and Autism Spectrum Disorder? The databases used were PEPSIC, BVS, SciELO, RIHS, CAPES, and BDTD. The descriptors used were: “social skills,” “autistic children,” and “children with Autism Spectrum Disorder.” In the PEPSIC database, two articles were found; in BVS, one article; in SciELO, none; in RIHS, two dissertations; in CAPES, one article; and in BDTD, five studies, totaling eleven studies. The results suggest that behavioral problems and special needs are directly related to social skills. It is concluded that future research should further explore the relationship between ASD and social skills, as this not only allows for the prediction of behavioral problems but also supports more effective intervention practices.
NEUROPSYCHOLOGICAL REHABILITATION AND NON-INVASIVE STIMULATION IN AUTISM
Autism Spectrum Disorder (ASD) is characterized by persistent impairments in communication, social interaction, and stereotyped behaviors, significantly affecting daily functioning and social inclusion. Cognitive deficits involving executive functions, attention, working memory, and social cognition hinder educational, professional, and interpersonal performance. This study presents an integrative literature review of interventions combining neuropsychological rehabilitation with non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), with a particular focus on social cognition. Studies published between 2014 and 2025 were selected from the PubMed, Scopus, SciELO, and PePSIC databases, including interventions that assessed theory of mind, emotional regulation, or facial emotion recognition. The analysis considered stimulation parameters, characteristics of cognitive interventions, assessment instruments, and reported outcomes. The findings indicate that tDCS applied to the dorsolateral prefrontal cortex in combination with cognitive training promotes improvements in social cognition and communication, whereas rTMS demonstrates positive but more variable effects. Common methodological limitations include heterogeneous procedures, small sample sizes, and the lack of longitudinal follow-up. It is concluded that hybrid interventions combining neuromodulation and neuropsychological rehabilitation represent a promising approach to optimizing social cognitive functions in individuals with ASD, reinforcing the need for standardized protocols and multicenter studies.
PARENTALIDADE ATÍPICA E DESIGUALDADE SOCIAL
O exercício da parentalidade atípica, especialmente de crianças e jovens com Transtorno do Espectro Autista (TEA), enfrenta desafios singulares. Este artigo, de caráter qualitativo e bibliográfico, analisa os obstáculos enfrentados por pais e responsáveis, com ênfase nas desigualdades sociais, culturais e econômicas brasileiras. A pesquisa indica que o acesso limitado a informações, medicamentos, tratamentos e serviços de apoio compromete essa parentalidade e pode enfraquecer vínculos sociais e gerar sensação de desesperança. Por outro lado, a proatividade das famílias, aliada ao apoio de políticas públicas e serviços de proteção social, como o CRAS, surge como estratégia essencial para superar essas adversidades. Conclui-se que o acesso a direitos e a uma rede de apoio robusta é decisivo para enfrentar os desafios da exclusão social na parentalidade atípica.
This article aims to analyze the impacts of social media on the emotional development and affective bonds of adolescents, reflecting on how hyperconnectivity interferes with identity construction and interpersonal relationships. This is a theoretical-reflective study, based on a review of contemporary literature addressing the psychological and social aspects of juvenile behavior in the digital era. The analysis discusses how the virtual environment, while expanding possibilities for expression and belonging, also contributes to the weakening of affective bonds and the superficialization of social interactions. It was observed that excessive use of social media can lead to emotional isolation, dependence on external validation, and difficulties in empathic communication, compromising the quality of relationships and the development of a solid identity. It is concluded that understanding these phenomena is essential for psychology professionals and students to develop sensitive listening skills and intervention strategies aimed at the conscious use of technology, strengthening human contact and the emotional health of young people. Thus, a necessary reflection is proposed: how to promote genuine and balanced affective bonds in a generation that is increasingly connected, yet emotionally distant?
THE PERCEPTION OF PROFESSIONALS IN A FAMILY HEALTH UNIT REGARDING RECEPTION (USER EMBRACEMENT) AND ITS INTERFACE WITH THE ATTRIBUTES OF PRIMARY HEALTH CARE
This qualitative study aimed to understand the perception of user embracement by professionals at a Family Health Unit. A semi-structured interview was used, identifying four core meanings: " User embracement and Primary Health Care Attributes," "Training on user embracement," "Knowledge and Implementation of user embracement," and "Culture of Health Service Utilization." This mechanism was recognized according to the National Humanization Policy and interconnected with the essential attributes of Primary Health Care; it is also related to extramural actions, popular education, triage, physical space, and scheduling of appointment slots. Changes in the agenda structure and continuing education actions are suggested, focusing on user embracement and interprofessionality, to improve health management and work processes.
THE ROLE OF EARLY INTERVENTION IN THE NEUROPSYCHOMOTOR DEVELOPMENT OF CHILDREN WITH ASD
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by changes in communication, sociability, and repetitive and stereotyped behaviors. Its prevalence has increased in Brazil, affecting approximately one in every 38 children. In this context, early intervention (EI) stands out as an essential approach to minimize the impacts caused by the disorder. Thus, the objective was to analyze the effects of EI on the neuropsychomotor development of children with ASD. This was an integrative literature review, in which eight studies related to the theme were identified. The results highlight impacts on neuropsychomotor development in its various dimensions, demonstrating the feasibility of EIs. It is concluded that EIs are feasible and effective in neuropsychomotor development, especially in early childhood. Despite the promising results, further studies focused on the applicability of different approaches are still needed.
THE ROLE OF OCCUPATIONAL THERAPY IN SENSORY REGULATION OF CHILDREN WITH ASD IN THE AMAZON
The perspective of Occupational Therapy makes it possible to understand the individual in an integral way, considering their neurological, sensory, motor, behavioral, and cognitive aspects, as well as the context in which they are inserted. This view seeks to expand intervention possibilities beyond the traditional clinical setting. This article aims to report the experience of an occupational therapist in assisting children with Autism Spectrum Disorder (ASD) in the Amazon region through the Multidisciplinary Inclusive Education Center (NEIAM), linked to the Vale do Trombetas Foundation. The intervention, grounded in the Sensory Integration approach, sought to describe the role of Occupational Therapy in the sensory regulation of children with ASD living in the village of Porto Trombetas, municipality of Oriximiná (PA). It is based on the principle that, through this approach, patients with Sensory Processing Disorder (SPD) may develop adaptive responses that favor their integral development.
THE CARE OF CHILDREN WITH AUTISM SPECTRUM DISORDER IN SHELTER INSTITUTIONS
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by differences in communication, social interaction, and behavior. This study aims to reflect on the care and early intervention strategies offered to a child with ASD in early childhood who was sheltered in a Shelter Service for Children and Adolescents (SAICA) in São Paulo. This is a qualitative experience report based on the researcher’s experience as a volunteer and Psychology student, conducted under faculty supervision. Limitations in verbal and nonverbal communication, intense emotional responses, difficulties in sharing, and a tendency toward isolation were observed. Bond-building and play proved to be fundamental strategies for early intervention. The need for professional preparation to work in contexts of vulnerability was observed, especially in the absence or fragility of family bonds. It is expected that this study will contribute to valuing sensitive and personalized care for children with ASD in institutional shelter settings, emphasizing the importance of interventions directed toward their specific needs from early childhood onward.
IMPACTS OF TECHNOLOGIES ON PEOPLE WITH AUTISM SPECTRUM DISORDER
The advancement of digital technologies has significantly transformed the way individuals interact, learn, and process information. In the context of Autism Spectrum Disorder (ASD), these changes become especially relevant, since the virtual environment can act both as a facilitator and as an obstacle to cognitive and social development. This study aims to analyze the impacts of the use of digital technologies on people with ASD, highlighting the positive and negative effects of these tools. The research was conducted through a bibliographic review based on scientific publications published between 2020 and 2025 in the SciELO, PubMed, and PePsic databases. The results indicate that assistive technologies contribute to the improvement of communicative, executive, and social skills, promoting greater autonomy and inclusion. However, excessive screen use and prolonged exposure to digital stimuli may lead to dependency, sensory overload, and harm to mental health. It is concluded that the impact of technology on people with ASD is dual in nature, requiring conscious use guided by qualified professionals. Therefore, the development of interdisciplinary approaches that reconcile technological innovation, inclusion, and cognitive well-being becomes essential.
This study presents an integrative literature review on pragmatics in children with Autism Spectrum Disorder (ASD). This linguistic skill is characterized by the social use of language, enabling social interaction and overall development. The research analyzed 20 articles from the last 5 years, of which 9 met the inclusion and exclusion criteria. The main findings indicate recurring difficulties in maintaining conversational turns, interpreting communicative intentions, and adapting speech to the interlocutor. Such limitations directly impact social inclusion and school performance. The lack of standardization in assessment and intervention protocols was also highlighted as an obstacle to clinical advances. The article concludes that advances in research, as well as the development and validation of protocols in the Brazilian context, are necessary.
A TERAPIA ASSISTIDA POR ANIMAIS NO DESENVOLVIMENTO DE CRIANÇAS COM AUTISMO
A Terapia Assistida por Animais (TAA) constitui uma prática interdisciplinar que utiliza o vínculo humano-animal como recurso terapêutico e educacional, com o propósito de promover benefícios físicos, cognitivos, emocionais e sociais. Este estudo teve como objetivo analisar as contribuições da TAA para o desenvolvimento de crianças e adolescentes com Transtorno do Espectro Autista (TEA), por meio de uma revisão integrativa da literatura e de um relato de experiência em um projeto terapêutico interdisciplinar. A revisão foi realizada nas bases SciELO, LILACS, PubMed e Scopus, considerando publicações entre 2008 e 2024. O relato de experiência envolveu sessões semanais com cães e cavalos, conduzidas por equipe multiprofissional. Os resultados apontaram melhora na comunicação, atenção, autorregulação emocional e desempenho motor, além do fortalecimento do vínculo afetivo e da socialização. Conclui-se que a TAA é uma prática eficaz e humanizadora, que favorece o desenvolvimento global e a inclusão social de pessoas com TEA, desde que conduzida de forma ética e interdisciplinar, com respeito ao bem-estar animal e às singularidades humanas.
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by the interaction of genetic and environmental factors that manifest uniquely in each individual, impacting different dimensions of life, such as social, communicative, motor, and sensory domains. Considering this complexity, the development of individualized and integrated therapeutic plans becomes essential, involving a multiprofessional team capable of addressing the specific demands of each individual. This article aims to analyze, through a literature review, the importance of integrated multiprofessional care for individuals with ASD, highlighting its benefits and challenges. The research was conducted in the SciELO and Google Scholar databases, covering publications from 2010 to 2025, using the keywords “integrated intervention,” “autism,” “multiprofessional team,” and “psychology,” applying the Boolean operator AND to refine the searches. The results indicate that integrated multiprofessional practice promotes autonomy, quality of life, and the strengthening of the therapeutic bond, contributing to interventions that are better adapted to the real needs of individuals.
PEDAGOGICAL PRACTICES FOCUSED ON CHILDREN WITH ASD
Autism Spectrum Disorder (ASD) affects areas such as social skills, communication, and behavior, making the learning process a challenge for educators. This study aimed to analyze works that address pedagogical practices focused on students with ASD, seeking to understand strategies that promote the inclusion and development of these students. The research is justified by the interest in deepening knowledge in the field of special education and understanding how inclusion occurs in mainstream schools. The study is bibliographic in nature, based on books, scientific articles, and specialized publications on the subject.
The present study presents an experience report on the late diagnosis of autism spectrum disorder (ASD) in a 20-year-old young woman. The narrative seeks to explore, in a reflective and personal manner, the challenges faced throughout life without a formal diagnosis, the impacts of this absence on identity formation, relationships, and mental health, as well as the transformations that emerged after the recognition of autism. The methodology is grounded in autobiographical writing as a tool for reclaiming, analyzing, and re-signifying lived experiences. Supported by specialized literature on late diagnosis in autistic women, the report aims to articulate subjective and academic elements that highlight the importance of early recognition and qualified listening in the trajectories of autistic individuals. It concludes that the diagnosis, even when late, enables a profound process of self-understanding, emotional validation, and restructuring of daily life, promoting greater autonomy and social belonging.
Quando se fala sobre os cuidados ao TEA (Transtorno do Espectro Autista), as discussões sempre abordam a terapia ABA (sigla para Applied Behavior Analysis), o que pode acabar sendo um pouco restritivo, visto que por mais eficiente que seja, as lentes comportamentais podem acabar tirando um pouco a liberdade da criança com TEA para se expressar e ser no mundo. O trabalho não tem como objetivo criticar a terapia ABA, afinal, o campo comportamental produz condições e possibilidades muito boas para o cuidado. O trabalho tem como objetivo evidenciar como a aplicação de outras práticas podem ser benéficas para o cuidado com crianças com TEA. O estudo se trata de uma revisão bibliográfica por meio de bases de dados como Google Acadêmico, Scielo e PePSIC, além de leituras de autores renomados da área. As abordagens humanistas nos cuidados com o TEA têm como foco proporcionar para a criança a liberdade para exercer seu ser e sua subjetividade, sem depender necessariamente do diagnóstico. Além disso, é importante entender como a criança entende experiencia os fenômenos que a cercam, respeitando sua subjetividade, ao invés de tentar olhar pelas lentes de um transtorno.
CONSOLIDATION OF AN AMAZONIAN MODEL OF MULTIPROFESSIONAL REHABILITATION:
The present study describes the clinical and organizational impacts of the Center for Inclusive Education and Multidisciplinary Care (NEIAM), as an integral part of the Porto Trombetas Hospital, located in Western Pará, during the period from 2024 to 2025. The Amazonian model of multiprofessional rehabilitation is based on interdisciplinarity, daily integration among the fields of psychology, speech therapy, and occupational therapy, as well as systematic case discussions, fostering a practice centered on autonomy, independence, and family protagonism. On average, 85 patients were assisted monthly, including children and adolescents with atypical development, such as Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and Intellectual Developmental Disorder (IDD). They were followed by up to three specialties, with significant results and a substantial reduction in the waiting list due to the agility of the screening process and joint assessment. The experience confirms the importance of integrated models aligned with the guidelines of the World Health Organization (WHO), which advocates family-centered rehabilitation and shared responsibility in the therapeutic process. It is concluded that the NEIAM/HPTR model represents a sustainable, replicable, and humanized practice of multiprofessional rehabilitation in the Amazon.
PERFORMANCE OF THE OCCUPATIONAL THERAPIST IN THE SCHOOL INCLUSION OF STUDENTS WITH AUTISM SPECTRUM DISORDER (ASD) IN EARLY CHILDHOOD EDUCATION
The objective of this study was to identify and analyze the scientific production on the possibilities of occupational therapists’ actions in early childhood education with students with Autism Spectrum Disorder in Brazil. An integrative review was conducted, considering the period from 2012 to 2025, in English, Portuguese, and Spanish, using the descriptors: “Autism Spectrum Disorder,” “Autistic Disorder,” “Occupational Therapy,” “Early Childhood Education,” “Inclusive Education,” and “School Inclusion.” The information sources considered were: Embase, Web of Science, MEDLINE/PubMed, EBSCO, Virtual Health Library, and ERIC. The final sample consisted of three studies. The results demonstrated that the occupational therapist’s performance supports the school inclusion process through actions carried out in collaboration with the school team and families, contributing to independence and autonomy, as well as promoting students’ school participation. The study indicates that the lack of clear definition of the professional role, combined with the absence of legal frameworks for hiring—whether in support teams or directly within schools—represents a challenge to the effective implementation of practice in this context. It is concluded that the scientific literature is limited, highlighting the need for further research on the role of occupational therapists in the school context with children with Autism Spectrum Disorder.
CARE AND INTERVENTIONS IN EARLY CHILDHOOD:
Autism Spectrum Disorder (ASD) represents a significant challenge for child development, requiring specialized interventions from the earliest years of life. This review study aims to analyze the scientific evidence on care and interventions in early childhood, with emphasis on the effectiveness of early intervention in children with ASD. The methodology was based on a narrative literature review, including articles published between 2014 and 2024 in national and international scientific databases. The results demonstrate that interventions initiated between 18 and 36 months promote significant improvements in adaptive functioning, language, social interaction, and cognition. Approaches such as ABA, the Denver Model, PECS, TEACCH, and national initiatives such as the Integrated Program for Autism (PIPA) and the Better Early Childhood Program (PIM) are highlighted. It is concluded that equitable access, professional training, and intersectoral action are essential to ensure comprehensive and inclusive care for children with ASD in Brazil.
CONTRIBUTIONS OF AUGMENTATIVE AND ALTERNATIVE COMMUNICATION IN A SUMMER CAMP
Objective: To describe the contributions of Augmentative and Alternative Communication in a summer camp for adults with disabilities on an island in the United States, from the perspective of a healthcare professional. Method: A descriptive and observational experience report conducted during the month of August 2024, based on observation and lived experience in a summer camp located on an island on the northeastern coast of the United States of America. Results: It was possible to observe the method of Augmentative and Alternative Communication being used in various ways during the camp, ranging from software and applications to printed images on paper and gestures. Conclusion: The use of Augmentative and Alternative Communication by individuals with neurological conditions proves to be effective in several aspects beyond communication skills, such as promoting inclusion, understanding, improvement of social skills, and independence.
HOSPITALIZATIONS DUE TO MYCOSES IN SÃO LUÍS, MARANHÃO:
Mycoses are fungal infections prevalent in tropical and subtropical regions, with higher risk among immunosuppressed patients. This study describes hospitalizations due to mycoses in São Luís, Maranhão, between January 2023 and June 2025, using data from the SIH/DATASUS. Variables such as sex, age group, race/color, average length of hospital stay, and deaths were analyzed. A predominance of hospitalizations was observed among men and adults aged 30 to 49 years, with higher occurrence among mixed-race (pardo) patients. The average length of hospital stay was longer among women, and deaths were concentrated in immunocompromised individuals. Socioeconomic, environmental, and racial factors influence vulnerability to infections. Antifungal resistance and underreporting hinder clinical management and epidemiological surveillance. The results highlight the need for prevention strategies, early diagnosis, and targeted public policies to reduce morbidity and mortality caused by mycoses in the local population.
FUNCTIONAL YOGURT WITH BACURI (PLATONIA INSIGNIS MART.):
The search for healthy foods has driven the dairy sector to invest in innovative products, such as yogurts with regional fruits. The objective of this study was to develop whole probiotic yogurt flavored with bacuri and to evaluate its microbiological, physicochemical, and sensory characteristics. Two formulations were produced: F1 whole (Docina® + bacuri) and F2 probiotic (Bio-Rich® + Docina® + bacuri). Microbiological analyses (Salmonella sp., molds, yeasts, and E. coli), physicochemical analyses (pH, soluble solids, titratable acidity), and sensory analyses (acceptability, purchase intention, acceptability index) were performed. Sensory analysis results were evaluated using Student’s t test (p < 0.05). A significant difference was observed only for aroma, with F1 presenting slightly higher mean values for aroma, color, and flavor, while F2 was slightly superior in texture. Both F1 and F2 showed an acceptability index ≥ 70%. Market research indicated a positive purchase intention, highlighting F1. Physicochemical parameters met legal standards, and microbiological conditions were adequate. The potential of bacuri as an innovative ingredient is therefore concluded.
INHIBITION OF STAPHYLOCOCCUS AUREUS STRAINS BY SECONDARY METABOLITES OF STREPTOMYCES SP.
Streptomyces is recognized for its ability to produce bioactive compounds with antimicrobial activity. This study evaluated the activity of metabolites from Streptomyces sp. against clinical strains of Staphylococcus aureus. The extract was obtained by submerged fermentation, followed by antimicrobial activity assays, agar diffusion tests, and determination of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Standard strains ATCC 25923, ATCC 29213, and the clinical strain IC 2141 were tested. The extract showed inhibition zones ranging from 17 ± 0.82 mm to 19.33 ± 1.15 mm. MIC and MBC analyses revealed significant inhibitory and bactericidal activity, with emphasis on strain IC 2141 (MIC and MBC of 625 µg/mL). The results demonstrate that Streptomyces produces metabolites with antibacterial potential, including activity against strains resistant to conventional antibiotics. It is concluded that actinobacteria represent a promising source of bioactive compounds, reinforcing the importance of microbial bioprospecting in the development of therapeutic alternatives.
IDENTIFICATION OF YEASTS ISOLATED AT THE ANIL WASTEWATER TREATMENT PLANT IN SÃO LUÍS, BRAZIL
Wastewater Treatment Plants (WWTPs) are fundamental to maintaining basic sanitation, and the regularity of their operations is of utmost relevance to public health. The present study aims to understand key information regarding the pathogenicity of yeasts isolated from the Anil WWTP in São Luís, Maranhão. Samples were obtained from different operational stages of the Anil WWTP, followed by isolation, identification by MALDI-TOF, and preservation. This study highlights the main findings of the isolation, including C. parapsilosis, C. tropicalis, C. glabrata, C. krusei, C. metapsilosis, and H. opuntiae, as well as the main conclusions regarding the epidemiology and pathogenicity of these yeasts, considering the presence of C. parapsilosis and C. tropicalis on the WHO Fungal Priority Pathogens List (FPPL). Finally, further in-depth studies on the virulence and clinical aspects of the identified yeasts are suggested, as well as assessments of the impact of these microorganisms on public health in São Luís.
IN SILICO ANALYSIS OF THE THERAPEUTIC POTENTIAL OF SPILANTHOL IN THE MANAGEMENT OF PAIN AND INFLAMMATION IN PERISTOMAL DERMATITIS:
This study investigated, through computational (in silico) simulations, the therapeutic potential of spilanthol, a compound extracted from the jambu plant (Spilanthes acmella), for treating pain and inflammation in peristomal dermatitis. Using network pharmacology, 29 molecular targets common to spilanthol and the disease were identified, with emphasis on the proteins NFKB1, PIK3CG, PIK3CA, and CCR2, which are crucial in inflammatory processes. Pharmacokinetic profile analysis (ADMET) indicated that spilanthol has favorable drug-like characteristics, despite potential risks of skin sensitization. Molecular docking confirmed the high binding affinity of spilanthol to the key targets PIK3CG and CCR2, validating its mechanism of action. The results position spilanthol as a promising multitarget agent for the development of new therapies for peristomal dermatitis, requiring experimental validation.
HOSPITALIZATIONS FOR DIARRHEAL DISEASES AND THEIR RELATIONSHIP WITH BASIC SANITATION IN MARANHÃO, 2024
Diarrheal diseases constitute an important public health problem, especially in contexts with structural deficits in basic sanitation. This study analyzed the profile of hospitalizations in Maranhão between January and December 2024, based on data from DATASUS and the Brazil Sanitation Panel. The results showed a predominance of hospitalizations among children aged 1 to 4 years, confirming the immunological and environmental vulnerability of this group; however, young adults also presented expressive values, expanding the social and economic repercussions of the condition. A higher frequency of emergency care and a predominance of individuals of mixed race (pardo) among hospitalized patients were observed, indicating the influence of social determinants. A seasonal pattern was also identified, with an increase during the rainy months, when environmental conditions favor the spread of pathogens. These findings reinforce the association between inadequate sanitation and diarrheal morbidity, highlighting the need for intersectoral public policies.
This review study aims to analyze the inclusion of autistic women in the labor market, with an emphasis on the challenges related to social invisibility and late diagnosis. The literature indicates that, although there have been advances in diversity and inclusion policies, autistic women remain in a position of greater vulnerability due to the combination of gender-related barriers and a lack of awareness regarding the specific characteristics of female autism. Late diagnosis, often resulting from patterns of social masking and gender stereotypes, contributes to more precarious professional trajectories and hinders access to appropriate support. The review also highlights that the invisibility of these women in the labor market is not limited to hiring practices but extends to job retention and career progression, in contexts that still lack awareness and inclusive accommodations. By bringing together national and international studies, this work seeks to understand how structural inequalities impact the professional lives of autistic women and which strategies may promote greater equity. Thus, the study intends to contribute to the scientific and social debate on the need for public policies, organizational practices, and awareness-raising actions that foster effective inclusion.
The differential diagnosis between Autism Spectrum Disorder (ASD) and Hearing Impairment (HI) represents a clinical challenge in early childhood, as both conditions may present with speech delay, lack of response to being called, and difficulties in social interaction. Early intervention is essential to ensure appropriate care and promote the child’s overall development. This review study aimed to analyze scientific evidence regarding diagnostic and therapeutic strategies that assist in differentiating between ASD and HI in children. Nine articles published between 2019 and 2025 were reviewed from the SciELO and LILACS databases, with free access and full text available. The results showed that objective audiological tests, such as Auditory Evoked Potentials (ABR and CAEP), combined with the application of standardized behavioral instruments, such as ADOS-2, M-CHAT, and CARS, contribute to more accurate diagnoses and individualized therapeutic approaches. The literature also highlights challenges faced by public services, such as limited availability of audiological examinations and the need for continuing education to train professional teams. Early interdisciplinary assessment, based on clinical and audiological findings, is crucial for differential diagnosis and for promoting communicative development in childhood.